Chun-Hau Chen Selected Research

Peptidylprolyl Isomerase (Prolyl Isomerase)

1/2020	Inactivation of the Prolyl Isomerase Pin1 Sensitizes BRCA1-Proficient Breast Cancer to PARP Inhibition.
4/2015	The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
4/2015	Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease.
7/2014	Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer.
7/2013	SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function.
6/2012	Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.
4/2011	Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.

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Chun-Hau Chen Research Topics

Disease

11	Neoplasms (Cancer) 01/2021 - 09/2007
5	Breast Neoplasms (Breast Cancer) 01/2020 - 07/2013
4	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 04/2015
3	Carcinogenesis 04/2015 - 06/2012
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 02/2019
2	Triple Negative Breast Neoplasms 01/2020 - 01/2018
2	Acute Promyelocytic Leukemia 01/2018 - 05/2015
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Asthma (Bronchial Asthma) 01/2018
1	Inflammation (Inflammations) 01/2018
1	Leukemia 01/2018
1	Liver Neoplasms (Liver Cancer) 01/2018
1	Tauopathies 07/2015
1	Chronic Traumatic Encephalopathy 07/2015
1	Traumatic Brain Injuries (Traumatic Brain Injury) 07/2015
1	Prostatic Neoplasms (Prostate Cancer) 08/2011

Drug/Important Bio-Agent (IBA)

7	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 01/2020 - 04/2011
4	Proteins (Proteins, Gene)FDA Link 01/2018 - 06/2012
3	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2020 - 05/2015
3	Death-Associated Protein KinasesIBA 01/2017 - 09/2007
2	IsomerasesIBA 01/2018 - 05/2015
2	Phosphotransferases (Kinase)IBA 01/2018 - 04/2011
2	Pharmaceutical PreparationsIBA 05/2015 - 06/2012
2	Proline (L-Proline)FDA Link 05/2015 - 04/2015
1	angiotensin I (1-7)IBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 01/2021
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2021
1	BRCA1 ProteinIBA 01/2020
1	olaparibIBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	Cathepsin BIBA 02/2019
1	Interleukin Receptors (Interleukin Receptor)IBA 01/2018
1	Interleukin-33IBA 01/2018
1	Arsenic Trioxide (Trisenox)FDA Link 01/2018
1	ArsenicIBA 01/2018
1	CytokinesIBA 01/2018
1	cis-trans-IsomerasesIBA 01/2018
1	MicroRNAs (MicroRNA)IBA 01/2018
1	Amyloid beta-PeptidesIBA 01/2016
1	peptide AIBA 01/2016
1	Amyloid (Amyloid Fibrils)IBA 01/2016
1	tau Proteins (tau Protein)IBA 07/2015
1	Phosphates (Orthophosphate)IBA 05/2015
1	GTP Phosphohydrolases (GTPases)IBA 04/2015
1	Peptide Hydrolases (Proteases)FDA Link 07/2013
1	sulfoenolpyruvateIBA 07/2013
1	NIMA-Interacting Peptidylprolyl IsomeraseIBA 07/2013
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 06/2012
1	Paclitaxel (Taxol)FDA LinkGeneric 06/2012
1	Oncogene Proteins (Oncogene Protein)IBA 06/2012
1	UbiquitinIBA 08/2011
1	Ligases (Synthetase)IBA 08/2011
1	Calmodulin (Calcium-Dependent Activator Protein)IBA 09/2007
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 09/2007
1	Class 2 Receptor-Like Protein Tyrosine PhosphatasesIBA 09/2007
1	Epidermal Growth Factor (EGF)IBA 09/2007
1	src-Family KinasesIBA 09/2007

Therapy/Procedure

5	Therapeutics 01/2021 - 05/2010